Title of article
New indolic non-peptidic HIV protease inhibitors from (S)-glycidol: synthesis and preliminary biological activity
Author/Authors
Lucia Chiummiento، نويسنده , , Maria Funicello، نويسنده , , Paolo Lupattelli، نويسنده , , Francesco Tramutola، نويسنده , , Pietro Campaner، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
5984
To page
5989
Abstract
A series of non-peptidic HIV protease inhibitors were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.
Keywords
peptidomimetics , Indole , Biological activity , HIV PR inhibitors
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097343
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