Title of article
Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol
Author/Authors
Béranger Duthion، نويسنده , , Thomas-Xavier Métro، نويسنده , , Domingo Gomez Pardo، نويسنده , , Janine Cossy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
11
From page
6696
To page
6706
Abstract
N-alkyl 1,2-amino alcohols were rearranged stereospecifically by using TFAA/Et3N. This rearrangement has been used to synthesize N-isopropyl-3-(aryloxy)-2-hydroxypropylamines, β-adrenergic blocking agents such as (S)-toliprolol and (S)-propanolol.
Keywords
rearrangement , 1 , 2-amino alcohols , Aziridinium , (S)-Toliprolol , (S)-Propanolol
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097551
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