α-Spiro endoperoxides: synthesis and evaluation of their antimalarial activities

Endoperoxides belonging to the G-factor family, containing a spiroalkane moiety in the α position to the O–O bond, have been synthesized via an autoxidation reaction on the corresponding dienol precursors. Methylated derivatives in the peroxyhemiketal position have also been prepared. The in vitro antimalarial activities are reported. Fe(II)-induced reduction on endoperoxides 8 and 9 have been studied.