Title of article
1,2-Dehydrogenation of steroidal 6-methylen derivatives. Synthesis of exemestane
Author/Authors
Andrés Marcos Escribano، نويسنده , , Francisco A. Bermejo، نويسنده , , Antonio Lorente Bonde-Larsen، نويسنده , , Jes?s Iglesias Retuerto، نويسنده , , Ignacio Herr?iz Sierra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
7587
To page
7590
Abstract
The development of an efficient dehydration method of steroidal 4-en-3-ones by using chloranil and BSTFA in the presence of triflic acid in refluxing toluene allowed us, starting from testosterone, to set a large-scale procedure for the synthesis of the anti-cancer drug exemestane in 70% overall yield.
Keywords
Steroids , Dehydrogenation , Chloranil , Exemestane
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097705
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