Title of article :
1,2-Dehydrogenation of steroidal 6-methylen derivatives. Synthesis of exemestane
Author/Authors :
Andrés Marcos Escribano، نويسنده , , Francisco A. Bermejo، نويسنده , , Antonio Lorente Bonde-Larsen، نويسنده , , Jes?s Iglesias Retuerto، نويسنده , , Ignacio Herr?iz Sierra، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
The development of an efficient dehydration method of steroidal 4-en-3-ones by using chloranil and BSTFA in the presence of triflic acid in refluxing toluene allowed us, starting from testosterone, to set a large-scale procedure for the synthesis of the anti-cancer drug exemestane in 70% overall yield.
Keywords :
Steroids , Dehydrogenation , Chloranil , Exemestane
Journal title :
Tetrahedron
Journal title :
Tetrahedron
