Title of article :
Radical deoxygenation of 3-azatricyclo[2.2.1.02,6]heptan-5-ols to 2-azabicyclo[2.2.1]hept-5-enes and 1,2-dihydropyridines
Author/Authors :
David M. Hodgson، نويسنده , , Matthew L. Jones، نويسنده , , Christopher R. Maxwell، نويسنده , , Andrew R. Cowley، نويسنده , , Amber L. Thompson، نويسنده , , Osamu Ichihara، نويسنده , , Ian R. Matthews، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Additions of alkyl or aryl Grignard reagents, or pyridin-3-yl-lithiums or lithium alkoxides, to exo-5,6-epoxy-7-(tert-butoxycarbonyl)-2-tosyl-7-azabicyclo[2.2.1]hept-2-ene lead to 7-substituted-1-tosyl-3-azatricyclo[2.2.1.02,6]heptan-5-ols. Radical deoxygenations of 7-alkyl-1-tosyl-3-azatricyclo[2.2.1.02,6]heptan-5-ols give 7-alkyl-4-tosyl-2-azabicyclo[2.2.1]hept-5-enes, whereas 7-aryl-1-tosyl-3-azatricyclo[2.2.1.02,6]heptan-5-ols give 2-(arylmethyl)-5-tosyl-1,2-dihydropyridines.
Journal title :
Tetrahedron
Journal title :
Tetrahedron
