Title of article
Oxidation of cationic 1,4-dihydropyridine derivatives as model compounds for putative gene delivery agents
Author/Authors
Aiva Plotniece، نويسنده , , Karlis Pajuste، نويسنده , , Dainis Kaldre، نويسنده , , Brigita Cekavicus، نويسنده , , Brigita Vigante، نويسنده , , Baiba Turovska، نويسنده , , Sergey Belyakov، نويسنده , , Arkadij Sobolev، نويسنده , , Gunars Duburs، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
8344
To page
8349
Abstract
A new synthetic approach to cationic pyridine derivatives is described here. Two different strategies for the synthesis of 1,1′-{[3,5-bis(ethoxycarbonyl)-4-phenylpyridine-2,6-diyl]dimethylene}bispyridinium salts have been developed. The key step of the first strategy relies on electrochemical and chemical oxidation of cationic 1,4-dihydropyridines; the second one involves nucleophilic substitution of pyridine dibromo derivatives.
Keywords
Oxidation , Gene delivery , 4-dihydropyridines and pyridines , Cationic 1
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097792
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