Author/Authors :
Aiva Plotniece، نويسنده , , Karlis Pajuste، نويسنده , , Dainis Kaldre، نويسنده , , Brigita Cekavicus، نويسنده , , Brigita Vigante، نويسنده , , Baiba Turovska، نويسنده , , Sergey Belyakov، نويسنده , , Arkadij Sobolev، نويسنده , , Gunars Duburs، نويسنده ,
Abstract :
A new synthetic approach to cationic pyridine derivatives is described here. Two different strategies for the synthesis of 1,1′-{[3,5-bis(ethoxycarbonyl)-4-phenylpyridine-2,6-diyl]dimethylene}bispyridinium salts have been developed. The key step of the first strategy relies on electrochemical and chemical oxidation of cationic 1,4-dihydropyridines; the second one involves nucleophilic substitution of pyridine dibromo derivatives.
Keywords :
Oxidation , Gene delivery , 4-dihydropyridines and pyridines , Cationic 1
