Author/Authors :
Leonardo Degennaro، نويسنده , , Vito Capriati، نويسنده , , Claudia Carlucci، نويسنده , , Saverio Florio، نويسنده , , Renzo Luisi، نويسنده , , Irene Nuzzo، نويسنده , , Corrado Cuocci، نويسنده ,
Abstract :
The synthesis of terminal oxazolinyloxiranes, even in enantioenriched form, has been performed by Darzens-type reaction of lithiated chloroalkyloxazolines with benzotriazolylmethanol (BtCH2OH) or by chloromethylation of 2-acyl-2-oxazolines. The synthetic utility of such oxiranes based on their ability to act either as electrophiles, undergoing ring-opening reactions with nucleophiles, or as nucleophiles in form of the oxiranyl anions, generated by stereoselective β-deprotonation, has been investigated.
