Title of article
Regioselective coupling reactions of 2,4-diaminopyridine derivatives with aryl halides: the synthesis of elaborated pyridines
Author/Authors
Matthew M. Bio، نويسنده , , Ed Cleator، نويسنده , , Antony J. Davies، نويسنده , , Simon E. Hamilton، نويسنده , , Andrew Lawrence، نويسنده , , Faye J. Sheen، نويسنده , , Gavin W. Stewart، نويسنده , , Robert D. Wilson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
8950
To page
8955
Abstract
The development of a synthetically useful, regioselective cross-coupling of 2,4-diaminopyridines with aryl and heteroaryl halides is reported. Selectivity for coupling through either amine is controlled by a simple change in the reaction conditions. Cross-coupling through the 2-amino group predominates in the presence of a palladium catalyst, whilst the 4-amino coupled product predominates in the absence of palladium.
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097866
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