Title of article :
New organocatalysts for the asymmetric reduction of imines with trichlorosilane
Author/Authors :
Andrei V. Malkov، نويسنده , , Kvetoslava Vrankov?، نويسنده , , Ralph C. Sigerson، نويسنده , , Sigitas Ston?ius، نويسنده , , Pavel Ko?ovsk?، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Asymmetric reduction of prochiral ketimines 1a–f with trichlorosilane can be catalyzed by the Lewis-basic formamides (S)-4a,b, derived from N-methyl valine, with ≤91% enantioselectivity and low catalyst loading (≤5 mol %) at room temperature in toluene.
Keywords :
Hydrosilylation , Organocatalysis , Lewis-basic catalysts , enantioselective reduction , Asymmetric catalysis , Trichlorosilane
Journal title :
Tetrahedron
Journal title :
Tetrahedron
