Title of article
New organocatalysts for the asymmetric reduction of imines with trichlorosilane
Author/Authors
Andrei V. Malkov، نويسنده , , Kvetoslava Vrankov?، نويسنده , , Ralph C. Sigerson، نويسنده , , Sigitas Ston?ius، نويسنده , , Pavel Ko?ovsk?، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
9481
To page
9486
Abstract
Asymmetric reduction of prochiral ketimines 1a–f with trichlorosilane can be catalyzed by the Lewis-basic formamides (S)-4a,b, derived from N-methyl valine, with ≤91% enantioselectivity and low catalyst loading (≤5 mol %) at room temperature in toluene.
Keywords
Hydrosilylation , Organocatalysis , Lewis-basic catalysts , enantioselective reduction , Asymmetric catalysis , Trichlorosilane
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1099228
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