Title of article
The first synthesis of 2-amino-1,4-dihydroquinolines
Author/Authors
Guillaume Viault، نويسنده , , Danielle Grée، نويسنده , , Thierry Roisnel، نويسنده , , Srivari Chandrasekhar، نويسنده , , René Grée*، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
10149
To page
10154
Abstract
A versatile strategy is described for the synthesis of new 2-amino-1,4-dihydroquinolines. It involved a Knoevenagel condensation of N-protected-2-amino-5-bromobenzaldehyde with ethylcyanoacetate, followed by a cyclization and protection of the NH group to afford the key intermediates 7 or 19. Then various 1,4 addition reactions have been performed to introduce substituents on the upper part of the 2-amino-1,4-dihydroquinolines.
Keywords
1 , 4-Dihydroquinolines , HA 14-1 , benzopyran , Anti-cancer , Bcl-2
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1100306
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