Author/Authors :
Paolo Quadrelli، نويسنده , , Bruna Bovio، نويسنده , , Achille Piccinini، نويسنده , , Pierluigi Caramella، نويسنده , , Francesco De Sarlo، نويسنده , , Fabrizio Machetti، نويسنده ,
Abstract :
A new approach to useful precursors for the synthesis of isoxazoline-carbocyclic nucleosides is detailed, starting from the readily available N-benzoyl-2,3-oxazanorborn-5-ene and introducing more polar and hydrophilic functionalities through 1,3-dipolar cycloaddition of carbethoxyformonitrile oxide, generated either from the corresponding hydroximoyl chloride or, more conveniently, by catalyzed condensation with ethyl nitroacetate.
