Title of article :
Efficient microwave-assisted two-step procedure for the synthesis of 1,3-disubstituted-imidazo[1,5-a]quinazolin-5-(4H)-ones
Author/Authors :
Flavia Jankowski، نويسنده , , Valérie Verones، نويسنده , , Nathalie Flouquet، نويسنده , , Pascal Carato، نويسنده , , Pascal Berthelot، نويسنده , , Nicolas Lebegue، نويسنده ,
Abstract :
A general method has been developed for the synthesis of 1,3-disubstituted-imidazo[1,5-a]quinazolin-5-(4H)-ones. This process involves initial microwave-assisted quinazolinone formation between anthranilamide and various Boc- or acylamino acids, followed by intramolecular cyclodehydration under acidic conditions. In the case of 3-monosubstituted-imidazoquinazolinones, the procedure needs the formation of the formamide derivatives by deprotection and formylation of the Boc-intermediates.
