Author/Authors :
Tsui-Hwa Tseng، نويسنده , , Shien-Kai Chuang، نويسنده , , Chao-Chin Hu، نويسنده , , Chia-Fu Chang، نويسنده , , Yu-Chao Huang، نويسنده , , Cheng-Wei Lin، نويسنده , , Yean-Jang Lee، نويسنده ,
Abstract :
Morusin, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol. In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described. Consequently, this strategy provided a concise route to synthesize the morusin analogues as well. Further biological studies of morusin, it exhibited strong antitumor effects with IC50 ∼3.0 μM on three cancer cells.
