Title of article
The synthesis of morusin as a potent antitumor agent
Author/Authors
Tsui-Hwa Tseng، نويسنده , , Shien-Kai Chuang، نويسنده , , Chao-Chin Hu، نويسنده , , Chia-Fu Chang، نويسنده , , Yu-Chao Huang، نويسنده , , Cheng-Wei Lin، نويسنده , , Yean-Jang Lee، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
6
From page
1335
To page
1340
Abstract
Morusin, which can be isolated from Chinese herbal medicine, is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol. In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described. Consequently, this strategy provided a concise route to synthesize the morusin analogues as well. Further biological studies of morusin, it exhibited strong antitumor effects with IC50 ∼3.0 μM on three cancer cells.
Keywords
Morusin , SnCl2 , EtSLi
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100555
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