Title of article
Efficient syntheses of 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide
Author/Authors
Ronald C. Bernotas، نويسنده , , Rebecca J. Dooley، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
2273
To page
2276
Abstract
Expeditious routes to 1,2,3,4,4a,5-hexahydro-pyrazino[2,1-c][1,4]benzothiazine-6,6-dioxide, a methylenesulfone-constrained arylpiperazine, have been developed. The key step forms the tricyclic system in a cascade of reactions via a 1,4-addition, nitrogen alkylation, and aromatic substitution sequence.
Keywords
Arylpiperazine , cascade reaction , aromatic substitution , Sulfones
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100658
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