Title of article :
Microwave-assisted synthesis of 4-amino-3,5-dihalopyridines
Author/Authors :
Mark Pichowicz، نويسنده , , Simon Crumpler، نويسنده , , B. Edward McDonald and William L. Siegmann، نويسنده , , Julian Blagg، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
4-Amino-3,5-dihalopyridines have been efficiently prepared via microwave-assisted nucleophilic aromatic substitution of 3,4,5-trihalopyridines using 1–1.1 equiv of primary and secondary amines. The reaction is also applicable to electron rich arylamines.
Keywords :
Coupling , nucleophilic aromatic substitution , Pyridines , Amines , Microwave-assisted synthesis
Journal title :
Tetrahedron
Journal title :
Tetrahedron
