Title of article
Chemo-promiscuity of alcohol dehydrogenases: reduction of phenylacetaldoxime to the alcohol
Author/Authors
Bianca Ferreira-Silva، نويسنده , , Iv?n Lavandera، نويسنده , , Alexander, Kern، نويسنده , , Kurt Faber، نويسنده , , Wolfgang Kroutil، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
3410
To page
3414
Abstract
The reduction of phenylacetaldoxime was catalysed by alcohol dehydrogenases in the presence of NAD(P)H yielding finally the primary alcohol via the imine and aldehyde intermediates. This suggests that the hydride of the cofactor NAD(P)H is transferred to the N-atom of the oxime moiety and not to the carbon atom, as usual stated. This reaction represents the first example of a catalytic chemo-promiscuity of alcohol dehydrogenases.
Keywords
Enzymes , Alcohol dehydrogenases , Reduction , aldoximes , Deoximation , Chemo-promiscuity
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100798
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