Title of article
Structure–reactivity relationships of l-proline derived spirolactams and α-methyl prolinamide organocatalysts in the asymmetric Michael addition reaction of aldehydes to nitroolefins
Author/Authors
Fintan Kelleher، نويسنده , , Sinead Kelly، نويسنده , , John Watts، نويسنده , , Vickie Mckee، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
12
From page
3525
To page
3536
Abstract
l-Proline derived spirolactams and α-methyl prolinamides act as organocatalysts for the asymmetric conjugate addition of aldehydes to nitroolefins in excellent yields, with good diastereoselectivity and enantioselectivity. Furthermore, low catalyst loadings (5 mol %) and a low aldehyde molar excess (1.5 M equiv) were achieved.
Keywords
Asymmetric organocatalysis , Spirolactam , Michael addition reaction , ?-Methyl prolinamide
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100814
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