Title of article :
Characteristic alkaline catalyzed degradation of kotalanol, a potent α-glucosidase inhibitor isolated from Ayurvedic traditional medicine Salacia reticulata, leading to anhydroheptitols: another structural proof
Author/Authors :
Osamu Muraoka، نويسنده , , Weijia Xie، نويسنده , , Satomi Osaki، نويسنده , , Ayumi Kagawa، نويسنده , , Genzoh Tanabe، نويسنده , , Mumen F.A. Amer، نويسنده , , Toshie Minematsu، نويسنده , , Toshio Morikawa، نويسنده , , Masayuki Yoshikawa، نويسنده ,
Abstract :
Stereochemical structure of kotalanol (2), a highly potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, was proved by alkaline catalyzed degradation of natural kotalanol (2), in which characteristic stereospecific cyclization of the degradative side chain leading to anhydroheptitols (10 and 11) was involved.
