Title of article
Synthesis of a small library of non-symmetric cyclic sulfamide HIV-1 protease inhibitors
Author/Authors
Anna Ax، نويسنده , , Advait A. Joshi، نويسنده , , Kristina M. Orrling، نويسنده , , Lotta Vrang، نويسنده , , Bertil Samuelsson، نويسنده , , Anders Hallberg، نويسنده , , Anders Karlén، نويسنده , , Mats Larhed، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
8
From page
4049
To page
4056
Abstract
A set of 11 non-symmetric cyclic sulfamide HIV-1 protease inhibitors were synthesized and evaluated. The use of a key microwave-assisted silver(I) oxide mediated selective mono N-benzylation reaction enabled fast and straightforward synthesis. The Ki values of the new inhibitors ranged between 0.28 μM and >20 μM.
Keywords
Benzylation , HIV-1 , Protease inhibitor , Palladium catalysis , Microwave
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100880
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