Title of article
The spiropiperidine-3,3′-oxindole scaffold: a type II β-turn peptide isostere
Author/Authors
Giordano Lesma، نويسنده , , Nicola Landoni، نويسنده , , Alessandro Sacchetti، نويسنده , , Alessandra Silvani، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
4474
To page
4478
Abstract
An unprecedented chiral spiropiperidine oxindole system was synthesized starting from enantiopure quaternary 3-aminooxindole and relying on a ring closing metathesis as the key step. This compound acts as an highly constrained Freidinger γ-lactam, adopting a type II β-turn conformation in solution, as assessed by modelling and spectroscopical studies.
Keywords
Conformation analysis , Oxindole , peptidomimetics , Spiro compounds , Metathesis
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100927
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