Author/Authors :
Chuanjun Song، نويسنده , , Peng Zhao، نويسنده , , Yan Liu، نويسنده , , Hui Liu، نويسنده , , Wenjia Li، نويسنده , , Shuai Shi، نويسنده , , Junbiao Chang، نويسنده ,
Abstract :
A new method for the synthesis of 3-halo-6-(N-tosyl-2-pyrrolyl)pyridazine 7 was developed. Suzuki cross-coupling reactions of 7 with arylboronic acids and in situ de-tosylation gave a variety of novel 3-aryl-6-(2-pyrrolyl)pyridazines. It found that protection of the pyrrolyl moiety was necessary for efficient coupling reaction.
Keywords :
Pyrrole acylation , Suzuki cross-coupling , nucleophilic aromatic substitution , 3-Aryl-6-(2-pyrrolyl)pyridazine , 3-Halo-6-(N-tosyl-2-pyrrolyl)pyridazine
