Author/Authors :
Diver Sellanes، نويسنده , , Francisco Campot، نويسنده , , Ivana N??ez، نويسنده , , Gerardo Lin، نويسنده , , Pablo Esp?sito، نويسنده , , Sylvia Dematteis، نويسنده , , Jenny Salda?a، نويسنده , , Laura Dom?nguez، نويسنده , , Eduardo Manta، نويسنده , , Gloria Serra، نويسنده ,
Abstract :
The synthesis of key fragments of scleritodermin A, their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed. Highlights of the synthetic route include formation of the α-ketoamide linkage and use of stereocontrolled reactions. Open analogs of this natural product were obtained using a convergent strategy.
Keywords :
Scleritodermin A analogs , azoles , ?-ketoamide , Key fragments
