A novel and convenient approach for tosyloxylation of aromatic ring of some ortho-substituted phenolic compounds using [hydroxy(tosyloxy)iodo]benzene

The oxidation of some substituted monohydric phenols, containing electron-withdrawing substituents at the ortho position to the phenolic group, with [hydroxy(tosyloxy)iodo]benzene (HTIB, Koser’s reagent) leads to novel tosyloxylation of aromatic ring, thereby offering a convenient synthesis of hitherto unknown 4-tosyloxy-2-substituted phenols.