Author/Authors :
Malte Brasholz، نويسنده , , Brian A. Johnson، نويسنده , , James M. Macdonald، نويسنده , , Anastasios Polyzos، نويسنده , , John Tsanaktsidis، نويسنده , , Simon Saubern، نويسنده , , Andrew B. Holmes، نويسنده , , John H. Ryan، نويسنده ,
Abstract :
A domino cyclization reaction of the bis-unsaturated ketone 3 with hydroxylamine proceeds with good yield and high stereoselectivity, in a flow reactor system. The tricyclic spiropiperidine products 5 and 2 obtained are valuable building blocks for the synthesis of analogues of the histrionicotoxin alkaloids.
Keywords :
Flow chemistry , domino reactions , Spiropiperidines , Olefination reactions , 1 , 3-dipolar cycloaddition
