Title of article
Synthesis of 3-substituted 3H-indol-3-ols by the reaction of 2-isocyanophenyl ketones with Grignard reagents
Author/Authors
Kazuhiro Kobayashi، نويسنده , , Yuta Okamura، نويسنده , , Shuhei Fukamachi، نويسنده , , Hisatoshi Konishi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
7961
To page
7964
Abstract
A facile method for the synthesis of 3-substituted 3H-indol-3-ols has been developed. Thus, 2-isocyanophenyl ketones are allowed to react with various Grignard reagents to give the corresponding desired indolol derivatives in generally fair to good yields. The formation of 3-aryl-2,3-dimethylindolin-3-ols by the reaction of 2-isocyanobenzophenones with 2 M amounts of methylmagnesium bromide is also reported.
Keywords
3H-Indol-3-ols , 2-Isocyanophenyl ketones , Grignard reagents , Indolin-3-ols , Imidoyl anions
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101335
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