Title of article :
Synthesis and DNA cleavage evaluation of epoxypiperidine derivatives bearing a dehydroamino acid unit
Author/Authors :
TAKAO YAMAGUCHI، نويسنده , , Yuji Kawada، نويسنده , , Satoshi Obika، نويسنده , , Takeshi Imanishi، نويسنده , , Kazuyuki Miyashita، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
Epoxypiperidine derivatives bearing a dehydroamino acid unit were designed and synthesized as novel DNA alkylating agents based on the structure of azinomycins. A relaxation assay of plasmid DNA revealed that the epoxypiperidine derivative 3 has a DNA cleavage activity. Based on the studies, it would appear that the electron density of the amino group of epoxypiperidines plays a critically important role in the DNA cleavage.
Keywords :
DNA cleavage , DNA alkylation , azinomycin , Dehydroamino acid , Epoxypiperidine
Journal title :
Tetrahedron
Journal title :
Tetrahedron
