Title of article :
Asymmetric Synthesis of 4-Quaternary 2-Deoxy-3-epi-P-C-Nucleosides
Author/Authors :
Enders، Dieter نويسنده , , Hieronyrni، Antje نويسنده , , Ridder، Andre نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
An efficient diastereo- and enantioselective synthesis of 4ʹ-quaternary 2ʹ-deoxy-3ʹ-epi-(beta)-C-nucleosides is described employing the RAMP-hydrazone methodology to establish the first stereocentre. Further key steps include diastereoselective nucleophilic 1,2-additions with Grignard and organocerium reagents.
Keywords :
asymmetric synthesis , nucleoside analogues , hydrazones , organocerium reagents , diastereoselective reduction
