Title of article
Iodine(III)-mediated ring expansion: an efficient and green pathway in the synthesis of a key precursor for the design of aminopeptidase (APN or CD13) inhibitors
Author/Authors
Lionel Roux، نويسنده , , Cédric Charrier، نويسنده , , Albert Defoin، نويسنده , , Philippe Bisseret، نويسنده , , Céline Tarnus، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
7
From page
8722
To page
8728
Abstract
Iodine(III)-mediated ring expansion of a methylidenebenzocyclohexane derivative into the corresponding benzosuberone was used as a key reaction for the obtention of an important precursor for the design of aminopeptidase (APN or CD13) inhibitors. It represents the first application of this environmentally friendly rearrangement to medicinal chemistry.
Keywords
aminopeptidase , Hypervalent iodine chemistry , ring expansion , APN or CD13 inhibitors
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102632
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