Title of article
Application of asymmetric phase-transfer catalysis in the enantioselective synthesis of cis-5-substituted proline esters
Author/Authors
Barry Lygo، نويسنده , , Christopher Beynon، نويسنده , , Michael C. McLeod، نويسنده , , Claude-Eric Roy، نويسنده , , Charles E. Wade، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
8832
To page
8836
Abstract
A simple, highly stereoselective three-step sequence for the enantioselective synthesis of cis-5-substituted proline esters is described. This sequence features an asymmetric PTC Michael addition, followed by acid catalysed imine exchange and catalytic hydrogenation. Application of this chemistry in the synthesis of the nonpeptide cholecystokinin antagonist (+)-RP-66803 11 is also described.
Keywords
Asymmetric catalysis , Michael addition , Hydrogenation , Amino acids , Pyrrolidines
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102646
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