Title of article
A novel and efficient synthesis of 3-aminomethyl-N-tosyl-indazoles
Author/Authors
Tuula Kylm?l?، نويسنده , , Antti H?m?l?inen، نويسنده , , Noora Kuuloja، نويسنده , , Jan Tois، نويسنده , , Robert Franzén، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
8
From page
8854
To page
8861
Abstract
A practical and environmentally friendly synthesis of 3-aminomethyl-N-tosyl-indazoles is developed. The in situ formed vinyl azines are reacted with amines to furnish amino functionalized anti-hydrazones in excellent yields. Subsequent copper-catalyzed cyclization at ambient temperature is effective and desired compounds are obtained in short reaction times. Also, the formation of bisindazoles is presented for the first time.
Keywords
Cyclization , Bisindazole , anti-Selective , copper , Indazole
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102649
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