Title of article
Chiral primary amine thiourea promoted highly enantioselective Michael reactions of isobutylaldehyde with maleimides
Author/Authors
Jian-Fei Bai، نويسنده , , Lin Peng، نويسنده , , Liang-liang Wang، نويسنده , , Li-Xin Wang، نويسنده , , Xiao-Ying Xu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
8928
To page
8932
Abstract
Chiral primary amine thiourea catalysts were first successfully applied to promote Michael addition of isobutyraldehyde to maleimides. A variety of N-aryl and N-aliphatic maleimides provided Michael adducts in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) with 5 mol % catalyst.
Keywords
Michael reactions , Isobutylaldehyde , Enantioselective , Primary amine thiourea , Maleimides
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102659
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