Author/Authors :
Samiul M. Ahad، نويسنده , , Alison L. Ange، نويسنده , , Robert B. Bates، نويسنده , , Bonnie L. Bell، نويسنده , , Adria A. Bodour، نويسنده , , Bryan R. Bourne، نويسنده , , Cristina G. Contreras، نويسنده , , Emily L. Goldberg، نويسنده , , A.A. Leslie Gunatilaka، نويسنده , , Sheryl King، نويسنده , , Albert K. Lee، نويسنده , , Rebecca L. Low، نويسنده , , Raina M. Maier، نويسنده , , Kathryn M. Marlor، نويسنده , , Marilyn T. ، نويسنده ,
Abstract :
Syntheses of the bacterial surfactants 6S,6S-, 9S,9S-, and 9U,9U-flavolipids confirmed the structures proposed for them from spectroscopic analysis of a flavolipid mixture and made pure flavolipids available for the first time. All three synthetic flavolipids and a straight chain analogue were found to be weakly cytotoxic and to inhibit metastatic cancer cell migration, with 9U,9U-flavolipid (the most abundant natural flavolipid) having the most activity. Biosynthetic routes to the branched side-chains of the flavolipids are suggested, and it is proposed that branched chains are employed to hinder biodegradation.
Keywords :
Siderophore , Biosurfactant , Flavobacterium , Flavolipid
