Title of article
A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents
Author/Authors
Tuan Minh Nguyen، نويسنده , , Nguyen Quang Vu، نويسنده , , Jean Jacques Youté، نويسنده , , Jacelyn Lau، نويسنده , , Angie Cheong، نويسنده , , Ying San Ho، نويسنده , , Benjamin S.W. Tan، نويسنده , , Kanagasundaram Yoganathan، نويسنده , , Mark S. Butler، نويسنده , , Christina L.L. Chai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
7
From page
9270
To page
9276
Abstract
The synthesis of the chiral core structure of the lissoclimide class of anti-tumour agents containing three rings, including a chiral succinimide subunit and an exocyclic double bond, has been investigated. The compound 7 was obtained, without the use of any protecting groups for the alcohol at C-12, via an asymmetric boron-mediated aldol addition as the key step to install the chiral centres of the rare succinimido methanol moiety. This was followed by a sequence of lactonisation, microwave-assisted amidation and imidation reactions.
Keywords
Lissoclimides , anti-Tumour agents , Natural products , Terpenoids , Aldol reaction
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102698
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