Author/Authors :
Tuan Minh Nguyen، نويسنده , , Nguyen Quang Vu، نويسنده , , Jean Jacques Youté، نويسنده , , Jacelyn Lau، نويسنده , , Angie Cheong، نويسنده , , Ying San Ho، نويسنده , , Benjamin S.W. Tan، نويسنده , , Kanagasundaram Yoganathan، نويسنده , , Mark S. Butler، نويسنده , , Christina L.L. Chai، نويسنده ,
Abstract :
The synthesis of the chiral core structure of the lissoclimide class of anti-tumour agents containing three rings, including a chiral succinimide subunit and an exocyclic double bond, has been investigated. The compound 7 was obtained, without the use of any protecting groups for the alcohol at C-12, via an asymmetric boron-mediated aldol addition as the key step to install the chiral centres of the rare succinimido methanol moiety. This was followed by a sequence of lactonisation, microwave-assisted amidation and imidation reactions.
Keywords :
Lissoclimides , anti-Tumour agents , Natural products , Terpenoids , Aldol reaction
