Author/Authors :
Jiang-Jiang Qin، نويسنده , , Hui-Zi Jin، نويسنده , , Jiaxian Zhu، نويسنده , , Jian-Jun Fu، نويسنده , , Qi Zeng، نويسنده , , Xiangrong Cheng، نويسنده , , Yan Zhu، نويسنده , , Lei Shan، نويسنده , , Shou-De Zhang، نويسنده , , Yue-Xing Pan، نويسنده , , Wei-Dong Zhang، نويسنده ,
Abstract :
Twenty-two new sesquiterpenes were isolated from the aerial parts of Inula japonica Thunb., together with fifteen known ones. Their structures were determined by detailed spectroscopic analysis, X-ray diffraction studies, and modified Mosher method. All 37 compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, and most of isolates significantly inhibited the NO production with IC50 values in the range of 3.5–20 μM. Besides, results obtained in our studies provided a structure–activity relationship that would be used to design anti-inflammatory agents in the future.
Keywords :
Inula japonica Thunb. , sesquiterpenes , Structure–activity relationship (SAR) , Asteraceae , RAW264.7 macrophages , Nitric oxide (NO)
