Title of article
Cross-coupling reaction on N-(3,5-dibromo-2-pyridyl)piperazines: regioselective synthesis of 3,5-disubstituted pyridylpiperazines
Author/Authors
Hidemasa Hikawa، نويسنده , , Yuusaku Yokoyama، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
8
From page
9552
To page
9559
Abstract
Unsymmetrical 3,5-disubstituted pyridylpiperazines were prepared from tribromopyridine in three coupling reactions. Key to the success of the syntheses is the palladium-catalyzed regioselective cross-coupling reaction in the 3-position of N-(3,5-dibromo-2-pyridyl)piperazines.
Keywords
Palladium , C–C coupling , Regioselectivity , Cross-coupling , medicinal chemistry
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102737
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