Title of article
Pyrrolidine-ureas as bifunctional organocatalysts for asymmetric Michael addition of ketone to nitroalkenes: unexpected hydrogen bonding effect
Author/Authors
Xiaoyu Cao، نويسنده , , Jun-Cheng Zheng، نويسنده , , Yu-Xue Li، نويسنده , , Zhen-Cao Shu، نويسنده , , Xiu-Li Sun، نويسنده , , Bi-Qin Wang، نويسنده , , Yong Tang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
9703
To page
9707
Abstract
A series of pyrrolidine-urea bifunctional organocatalysts was efficiently synthesized and applied to the asymmetric Michael addition of ketone to nitroolefin. Theoretical study was performed to shed light on the origin of their different activities and revealed that the rigid structure formed between catalyst 1b with nitroolefin via double hydrogen bonding retarded the approach of nucleophilic enamine intermediate.
Keywords
Pyrrolidine-urea , Bifunctional , Organocatalyst , Michael addition , Nitroalkene
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102756
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