Author/Authors :
Mariantonietta D’Acunto، نويسنده , , Carmela Della Monica، نويسنده , , Irene Izzo، نويسنده , , Luciano De Petrocellis، نويسنده , , Vincenzo Di Marzo، نويسنده , , Aldo Spinella، نويسنده ,
Abstract :
The enantioselective synthesis of 3(S)-hydroxy polygodial and its acetyl derivative is described. The construction of the 3-hydroxy drimane skeleton was based on the titanium-catalyzed radical cyclization of (10S)-10, 11-epoxy-farnesyl acetate. Only underivatized 3(S)-hydroxy polygodial showed activity in assays on VR1 vanilloid receptor in HEK cells transfected with the human VR1.
