Title of article
An efficient Morita–Baylis–Hillman reaction for the synthesis of multifunctional 2-hydroxy-3-nitrobut-3-enoate derivatives
Author/Authors
Hsuan-Hao Kuan، نويسنده , , Raju Jannapu Reddy، نويسنده , , Kwunmin Chen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
9875
To page
9879
Abstract
An efficient thiourea promoted MBH reaction of various conjugated nitroalkenes with ethyl glyoxylate was developed. The desired multifunctional products, 2-hydroxy-3-nitro-4-aryl/alkylbut-3-enoate derivatives were obtained in good to high chemical yields (56–92%) with DMAP (20 mol %) under solvent-free conditions or imidazole (100 mol %) in the presence of water.
Keywords
Thiourea , Organocatalysis , Aqueous media , Morita–Baylis–Hillman reaction , Nitroalkenes
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1102778
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