Title of article
Highly enantioselective synthesis of α-fluoro-α-nitro esters via organocatalyzed asymmetric Michael addition
Author/Authors
Hai-Feng Cui، نويسنده , , Peng Li، نويسنده , , Xiao-Wei Wang، نويسنده , , Zhuo Chai، نويسنده , , Ying-Quan Yang، نويسنده , , Yue-Peng Cai، نويسنده , , Shizheng Zhu، نويسنده , , Gang Zhao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
312
To page
317
Abstract
Primary amines catalyzed the asymmetric Michael addition of ethyl 2-fluoro-2-nitroacetate to enones to provide chiral α-fluoro-α-nitro ester ketones with two contiguous stereogenic centers, one of which is a fluorinated quaternary chiral center, with excellent enantioselectivities and in moderate to good yields.
Keywords
Primary amine , Asymmetric Michael addition , Fluorinated , enantioselectivities
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1102827
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