Title of article
Scalable synthesis of methyl ent-isocopalate and its derivatives
Author/Authors
Si-Kai Hua، نويسنده , , Jing Wang، نويسنده , , Xi-Bo Chen، نويسنده , , Zhongyu Xu، نويسنده , , Bu-Bing Zeng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1142
To page
1144
Abstract
An efficient and convenient synthetic route was developed to prepare the tricycle diterpene intermediates 1–3 starting from commercially available (−)-sclareol. This improved approach involving four-step reactions provides large-scale (30–40 g) methyl ent-isocopalate in 61% overall yield, which could supply sufficient material for the synthesis of marine natural products containing tricyclic diterpenes.
Keywords
spongiane , (?)-Sclareol , Tricycle diterpene , Methyl ent-isocopalate
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1102930
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