Title of article
Highly enantioselective synthesis of α-trichloromethyldihydropyrans catalyzed by bifunctional organocatalysts
Author/Authors
Haifeng Wang ، نويسنده , , Peng Li، نويسنده , , Hai-Feng Cui، نويسنده , , Xiao-Wei Wang، نويسنده , , Jun-Kang Zhang، نويسنده , , Wen Liu، نويسنده , , Gang Zhao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
7
From page
1774
To page
1780
Abstract
The enantioselective Michael addition of α-cyanoketones to α,β-unsaturated trichloromethyl ketones was firstly reported. With a phenylalanine-derived bifunctional piperazine/thiourea catalyst, a series of α-trichloromethyldihydropyrans were obtained with up to 95% ee and 99% yield.
Keywords
Trichloromethyl ketones , Dihydropyrans , Bifunctional organocatalysts , Michael addition , Enantioselectivity
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103004
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