• Title of article

    Divergent and stereoselective synthesis of dafachronic acids

  • Author/Authors

    Antimo Gioiello، نويسنده , , Paola Sabbatini، نويسنده , , Emiliano Rosatelli، نويسنده , , Antonio Macchiarulo، نويسنده , , Roberto Pellicciari، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2011
  • Pages
    6
  • From page
    1924
  • To page
    1929
  • Abstract
    A new divergent synthesis of DAF-12 ligands, namely Δ4- and Δ7-dafachronic acid, is described starting from the natural bile acid hyodeoxycholic acid. Homologation of the side chain followed by stereoselective reduction of the Δ24 olefinic linkage, 6α-dehydroxylation and C3-oxidation affords dafachronic acids in good yields and high diastereoselectivity making this approach easily accessible and scalable.
  • Keywords
    ?4-Dafachronic acid , ?7-Dafachronic acid , DAF-12 , stereoselective hydrogenation
  • Journal title
    Tetrahedron
  • Serial Year
    2011
  • Journal title
    Tetrahedron
  • Record number

    1103021

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1103021