Author/Authors :
Zhengjun Quan، نويسنده , , Rong-Guo Ren، نويسنده , , Xiaodong Jia، نويسنده , , Yuxia Da، نويسنده , , Zhang Zhang، نويسنده , , Xicun Wang، نويسنده ,
Abstract :
N-Alkoxymethylation of heterocyclic compounds with diethyl phosphite via cleavage of P–O bond was investigated and a series of N3-ethoxymethylated heterocyclic compounds were synthesized. A mechanism in which diethyl phosphite acts as an efficient surrogate of ethanol was proposed and supported by several evidences.
Keywords :
N-Alkylation , P–O cleavage , Diethyl phosphite , N3-Substituted dihydropyrimidinones
