Title of article :
A Practical Diastereoselective Synthesis of syn-(alpha)-Hydroxyaminonitriles
Author/Authors :
Leclerc، Eric نويسنده , , Abdillah، Fatoumia نويسنده , , Almeras، Loic نويسنده , , Mangeney، Pierre نويسنده , , Vrancken، Emmanuel نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
An efficient and practical one pot two-step synthesis of syn-(alpha)hydroxyaminonitriles through an acylation-diastereoselective reduction sequence from lithiated (alpha)-aminonitrile is achieved.
Keywords :
amino alcohols , reduction , acyl cyanide , dynamic kinetic resolution , diastereoselectivity
