Author/Authors :
P. Basabe، نويسنده , , A. Blanco، نويسنده , , I.S. Marcos، نويسنده , , D. D?ez، نويسنده , , O. Bodero، نويسنده , , M. Mart?n، نويسنده , , J.G Urones، نويسنده ,
Abstract :
Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate.
Keywords :
sclareol , Pyridines , Phospholipase A2 , marine metabolites , Spongidines
