• Title of article

    A Facile and Efficient Synthesis of 3,5-Disubstituted Tetronic Acids in Aqueous Media Involving Acid-Catalyzed Intramolecular Oxa-Pyridylethylation

  • Author/Authors

    Pan، Wei نويسنده , , Liu، Jun نويسنده , , Liu، Xiang-Qun نويسنده , , Dong، Dewen نويسنده , , Bi، Xihe نويسنده , , Zhao، Yi-Lei نويسنده , , Sun، Shaoguang نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    -48
  • From page
    49
  • To page
    0
  • Abstract
    A facile and efficient one-pot synthesis of 3-[bis(alkyl­thio/alkylamino)methylene]-5-(pyridyl/quinoylmethyl) furan-2,4 (3H,5H)-diones 3 and 10, based on a sequential aldol condensation and lactonization reaction between (alpha)-oxo ketene-S,Sacetals 1 and pyridine/qinoline-carboxaldehydes 2 in aqueous media, has been developed. A mechanism involving an acidcatalyzed intramolecular oxa-pyridylethylation reaction is proposed for the ­formation of the lactone ring.
  • Keywords
    tetronic acid derivatives , aqueous media , oxa-pyridylethylation , (alpha)-oxo ketene-N,N-acetals , (alpha)-oxo ketene-S,S-acetals
  • Journal title
    Synlett
  • Serial Year
    2005
  • Journal title
    Synlett
  • Record number

    110328

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=110328