Title of article
Development of an N-sulfinyl prolinamide for the asymmetric aldol reaction
Author/Authors
MaryAnn T. Robak، نويسنده , , Melissa A. Herbage، نويسنده , , Jonathan A. Ellman، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
4412
To page
4416
Abstract
A new class of organocatalysts is reported that incorporates an N-sulfinyl amide in place of the carboxylic acid of proline to serve as a hydrogen bond donor, chiral directing group, and solubilizing element. The successful application of this type of catalyst to the asymmetric aldol reaction of acetone and aryl aldehydes, for which proline performs poorly, is also described.
Keywords
Asymmetric catalysis , tert-Butanesulfinamide , Organocatalysis , Aldol reaction , proline
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103318
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