Author/Authors :
Masafumi Ueda، نويسنده , , Yuki Ikeda، نويسنده , , Aoi Sato، نويسنده , , Yuta Ito، نويسنده , , Maiko Kakiuchi، نويسنده , , Hiroko Shono، نويسنده , , Tetsuya Miyoshi، نويسنده , , Takeaki Naito، نويسنده , , Okiko Miyata، نويسنده ,
Abstract :
A facile and practical synthesis of 3,5-disubstituted isoxazoles via a silver-catalyzed cyclization and subsequent protonation of alkynyl oxime ethers has been developed. The methodology was successfully applied to the synthesis of a biologically active isoxazolecarboxylic acid.
Keywords :
Silver , Isoxazole synthesis , oxime ether , alkyne
