Title of article
A facile synthesis of 1,4-dideoxy-1,4-imino-l-ribitol (LRB) and (−)-8a-epi-swainsonine from d-glutamic acid
Author/Authors
Xiao-Ling Wang، نويسنده , , Wen-Feng Huang، نويسنده , , Xin-Sheng Lei، نويسنده , , Bang-Guo Wei، نويسنده , , Guo-Qiang Lin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
4919
To page
4923
Abstract
A facile synthesis of (−)-8a-epi-swainsonine 2 and 1,4-dideoxy-1,4-imino-l-ribitol (LRB) 4 has been achieved by using the versatile building block 3, which was available from cheap d-glutamic acid. The new forming stereogenic center in synthesis of 2 was constructed by highly selective reduction of the ketone 13 with Li(t-BuO)3AlH in THF (dr=95:5).
Keywords
LRB , Alkaloid , Asymmetric synthesis , Lactam , Swainsonine
Journal title
Tetrahedron
Serial Year
2011
Journal title
Tetrahedron
Record number
1103394
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