Title of article :
Photoactivated 1,3-dipolar cycloaddition for the rapid preparation of 18F labelled radiotracers
Author/Authors :
David Thonon، نويسنده , , Eve Goukens، نويسنده , , Geoffroy Kaisin، نويسنده , , Jérôme Paris، نويسنده , , Jessica Flagothier، نويسنده , , André Luxen، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
An 18F-labelled 2,5-diaryl tetrazole reagent has been prepared and reacted with substituted alkene dipolarophiles through a photoactivated 1,3-dipolar cycloaddition reaction. The radiobioconjugation reaction furnished the desired product in 5 min with radiochemical conversions of 85–95% at room temperature. Remarkably, for the activated dipolarophiles, these results were obtained in highly dilute solutions (10–100 μM).
Keywords :
Fluorine-18 , 2 , Radiolabelling , Radiopharmaceutical , Photoclick chemistry , 5-Diaryl tetrazole
Journal title :
Tetrahedron
Journal title :
Tetrahedron
